Symbol
Name
ID

Smad4
SMAD family member 4
MGI:894293

Phenotype annotations related to reproductive system

Darker colors indicate more annotations

Human Phenotypes	Ovarian neoplasm	Dysgerminoma	Ovarian carcinoma	Ovarian papillary adenocarcinoma	Endometrial carcinoma
Disease(s) Associated with SMAD4	Ovarian neoplasm	Dysgerminoma	Ovarian carcinoma	Ovarian papillary adenocarcinoma	Endometrial carcinoma
Lynch syndrome
ovarian cancer
pancreatic cancer

Mouse Phenotypes

decreased oocyte number

azoospermia

decreased male germ cell number

absent primordial germ cells

increased male germ cell apoptosis

abnormal ovarian follicle morphology

abnormal granulosa cell morphology

increased secondary ovarian follicle number

decreased tertiary ovarian follicle number

abnormal ovarian folliculogenesis

abnormal cumulus expansion

absent cumulus expansion

abnormal secondary ovarian follicle morphology

small seminiferous tubules

seminiferous tubule degeneration

increased Leydig cell number

decreased testis weight

small testis

increased ovary tumor incidence

abnormal male meiosis

arrest of spermatogenesis

decreased ovulation rate

decreased litter size

infertility

male infertility

Availability

Mouse Genotype

Smad4^m4Mag/Smad4⁺

Tg(Amh-Smad4)1Tkw/0

Smad4^tm2.1Cxd/Smad4^tm2.1Cxd
Tg(Dppa3-cre/Esr1*)3Sait/0 (conditional)

Smad4^tm2.1Cxd/Smad4^tm2.1Cxd
Tg(Pou5f1-cre/ERT2)#Ysa/0 (conditional)

Amhr2^tm3(cre)Bhr/Amhr2⁺
Smad4^tm1Rob/Smad4^tm1.1Rob (conditional)

Smad4^tm1Rob/Smad4^tm1.1Rob
Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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